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KMID : 1214920210270020071
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Soonchunhyang Medical Science
2021 Volume.27 No. 2 p.71 ~ p.74
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Association of Body Mass Index and Waist Circumference with Prostate-Specific Antigen
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Lee Jin
Shin Hwang-Sik
Cho Yong-Jin
Oh Jeung-Eun
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Abstract
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Objective: Prostate-specific antigen (PSA) is widely used as a screening tool of prostate cancer, although there has been a controversy about efficacy. In Korea, rapid growth of obesity prevalence in adult men is a one of the biggest health problems. The objective of this study was to evaluate the potential association between body mass index (BMI), waist circumference (WC) and PSA.
Method: We calculated BMI and WC of a total of 25,603 males who visited the Soonchunhyang University Cheonan Hospital Health Promotion Center from January 2016 to December 2020. This was categorized as follows: BMI < 23 kg/m2 (normal), 23 kg/m2 ≤ BMI < 25 kg/m2 (overweight), BMI ≥ 25 kg/m2 (obesity) and WC < 90 cm (normal), WC ≥ 90 cm (abdominal obesity). We analyzed the association between BMI, WC and PSA.
Results: The mean PSA value was 1.08 ng/mL, 1.03 ng/mL, and 0.97 ng/mL at normal, overweight, and obesity group, respectively. The mean PSA value was 1.04 ng/mL and 0.96 ng/mL at normal and abdominal obesity group. Thus, the mean PSA value decreased with an increase in BMI and WC category (P < 0.001). The correlation coefficient between BMI, WC and PSA was -0.055, -0.044 and they were statistically significant (P < 0.001).
Conclusion: We observed a significant negative correlation between BMI, WC and PSA value. Therefore, PSA value should be considered in relation to BMI and WC.
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KEYWORD
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Prostate-specific antigen, Obesity, Body mass index, Waist circumference
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